MOLECULAR DOCKING OF SELECTED COMPOUNDS FROM CLINACANTHUS NUTANS WITH BCL-2, P53, CASPASE-3 AND CASPASE-8 PROTEINS IN THE APOPTOSIS PATHWAY
نویسندگان
چکیده
منابع مشابه
Clinacanthus Nutans Hexane Extracts Induce Apoptosis Through a Caspase-Dependent Pathway in Human Cancer Cell Lines
Background: Clinacanthus nutans (C.nutans) is a plant consumed as a cancer treatment in tropical Asia. Despite the availability of numerous anecdotal reports, evaluation of active anticancer effects has remained elusive. Therefore we here examined antiproliferative, reactive oxygen species (ROS)-inducing and apoptosis mechanisms of whole plant extracts in different cancer cell lines. Methods: A...
متن کاملNicotine-induced damages in testicular tissue of rats; evidences for bcl-2, p53 and caspase-3 expression
Objective(s): Present study was performed in order to uncover new aspects for nicotine-induced damages on spermatogenesis cell lineage. Materials and Methods: For this purpose, 36 mature male Wistar rats were divided into three groups as; control-sham (0.2 ml, saline normal, IP), low dose (0.2 mg/kg BW-1, IP) nicotine-received and high dose (0.4 mg/kg BW-1, IP) nicotine-received groups. Followi...
متن کاملApoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent.
In the therapy of various kinds of tumors, methylating agents generating O6-methylguanine (O6MeG) in DNA are used. We studied the molecular mechanism of cell death induced by these agents by comparing isogenic cell lines proficient (MGMT+) and deficient (MGMT-) for the DNA repair protein alkyltransferase and exhibiting the tolerance phenotype. Hypersensitivity to methylation-induced cell killin...
متن کاملRole of caspase 3-dependent Bcl-2 cleavage in potentiation of apoptosis by Bcl-2.
Previous studies from our laboratory have demonstrated that Bcl-2 has a proapoptotic effect on neocarzinostatin (NCS)-treated PC12 pheochromocytoma cells. In the present study, we examine the mechanisms of this effect and demonstrate its relevance for the in vivo situation. Four hours after NCS treatment, a 23-kDa cleavage product of Bcl-2 was detected in whole cell lysates of bcl-2-transfected...
متن کاملnicotine-induced damages in testicular tissue of rats; evidences for bcl-2, p53 and caspase-3 expression
objective(s): present study was performed in order to uncover new aspects for nicotine-induced damages on spermatogenesis cell lineage. materials and methods: for this purpose, 36 mature male wistar rats were divided into three groups as; control-sham (0.2 ml, saline normal, ip), low dose (0.2 mg/kg bw-1, ip) nicotine-received and high dose (0.4 mg/kg bw-1, ip) nicotine-received groups. followi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological & Scientific Opinion
سال: 2020
ISSN: 2321-6328
DOI: 10.7897/2321-6328.081119